Interspire Email Marketer Mysql Error

Interspire Email Marketer gives the following error: "The application cannot proceed! An internal error occured. Please contact your administrator and describe the steps you took before you encounter this error message. Error msg: Unable to connect to the database. Please make sure the database information specified in admin/includes/[login to view URL] are correct." This is somehow related to settings (Server has 32GB Ram + 8core CPU) I already put settings memory_limit = 2048M and innodb_buffer_pool_size = 24G however problem is still existent and I need to reboot the server EVERY time to get all restarted.