Academic Writing project

£250-750 GBP

処理中

投稿日:

9年以上前

£250-750 GBP

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The Immunology Of Leishmania And Leishmaniasis In Humans Contents Abstract……………………………………………………………………………………………………………………………..3 Chapter 1 1.1 Introduction………………………………………………………………………………………………………....4 1.2 Epidemiology………………………………………………………………………………………………………..4 1.3 Types of Leishmaniasis…………………………………………………………………………………………5 1.3.1 Visceral Leishmaniasis……………………………………………………………………………………….6 1.3.2 Mucocutaneous Leishmaniasis……………………………………………………………………………7 1.3.3 Cutaneous Leishmaniasis……………………………………………………………………………………7 1.4 Life cycle of Leishmania………………………………………………………………………………………...9 1.4.1 First stage (from 0-2 days)………………………………………………………………………………..10 1.4.2 Stage two (from 2-5 days)…..…………………………………………………………………………….10 1.4.3 Stage three (after 5 days)………………………………………………………………………………….10 1.5 Human immune responses to Leishmaniasis and the role of Th1/Th2 during human infection…..………………………………………………………………………………………………………………11 Chapter 2 2.1 Immunology of Leishmania…………………………………………………………………………………14 2.1.1 T Lymphocytes…………………………………………………………………………………………………14 2.1.2 The role of B cells..……………………………………………………………………………………………14 2.1.3 The role of cytokines………………………………………………………………………………………...15 2.1.4 Immunosuppression………………………………………………………………………………………...15 2.2 Leishmania virulence factors……………………………………………………………………………….16 2.2.1 Lipophosphoglycan (LPG)………………………………………………………………………………...16 2.2.2 Acid phosphatases……………………………………………………………………………………………18 2.2.3 Glycoprotein 63 (GP60)……………………………………………………………………………………18 2.2.4 Cysteine proteinases (Cps)……………………………………………………………………………….18 Chapter 3 3.1 Interactions between Leishmania and the host macrophage…………………………………20 3.1.1 Interactions and phagocytosis…………………………………………………………………………..20 Chapter 4 4.1 Experimental models for Leishmaniasis………………………………………………………………21 4.1.1 Dog………………………………………………………………………………………………………………….22 4.1.2 Mouse……………………………………………………………………………………………………………...22 4.1.3 Hamster.………………………………………………………………………………………………………….23 Chapter 5 5.1 Vaccines against Leishmaniasis…………………………………………………………………………...24 5.1.1 Killed vaccines………………………………………………………………………….................................25 5.1.2 Live vaccines………………………………………………………………………….....................................25 5.1.3 Naked DNA vaccines………………………………………………………...............................................26 5.1.4 Live attenuated vaccines……………………………………………………….......................................27 References……………………………………………………………………………………………………………….28

Research Writing

プロジェクト ID: 6676859

プロジェクトについて

30個の提案

リモートプロジェクト

アクティブ 10年前

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